The Payoff

    Use when matched

    Creatine monohydrate

    Creatine has solid evidence for strength and training output, and a good safety record. The cognitive and longevity claims are far less settled.

    USE WHEN MATCHEDEvidence: Strong for strengthReviewed by the Beyond23 medical team

    One of the better-supported supplements for improving training-driven strength and lean mass.

    Cost and effort, honestly

    Cost
    Low
    Effort
    Low

    What the evidence supports

    Creatine combined with resistance training can produce greater gains in strength and lean mass than resistance training alone, including in older adults.

    Most relevant when

    Preserving or building muscle is a priority, particularly alongside a consistent resistance programme.

    Keep in perspective

    This is strong evidence for performance and body-composition outcomes — not proof that creatine extends lifespan.

    Safety

    Generally well tolerated, but people with kidney disease, pregnancy or complex medical conditions should discuss supplementation with a clinician.

    Sources

    Your payoff

    See whether this belongs in your plan, what it could realistically change, and where it ranks against your other options.

    • Personal relevance
    • Signals it may improve
    • Priority versus your alternatives
    • Recommended starting point
    • How we would track response

    Requires your health history, labs and available wearable data.

    Educational information, not a diagnosis or prescription. Medication decisions require consultation with a qualified clinician.